Abstract:
Background
Diabetic nephropathy is the most serious complication of diabetes which leads to end-stage
renal failure and other complication of diabetes mellitus. Determinants of Diabetic nephropathy are not consistent in different studies and associated factors to chronic complications
of diabetes are not specific and there are limited studies specific to diabetic nephropathy.
Thus, the aim of this study is to identify determinants of diabetic nephropathy in Ayder Referral Hospital, Northern Ethiopia.
Methods
A case-control study was conducted from February 14 to May 8 2016. Diabetic patients
who developed nephropathy in the last two years were the cases and diabetic patients free
of nephropathy were controls. Cases and controls were identified detailed review of the
chronic care follow up chart. Then simple random sampling was used to select sample of
420 (with control to case ratio of 4:1) resulting in 84 cases and 336 controls. Record review
and interviewer administered questionnaire were used to collect data. Data was coded and
entered in to Epi-Data version 3.1 and then exported to STATA 12 for analysis. Variables
with P-values< 0.25 in Bivariate logistic regression were selected for multiple logistic regressions to determine independent determinants of diabetic nephropathy. OR was calculated
with 95% CI to show strength of association.
