Synthesis, characterization and antibacterial study of a schiff base ligand derived from 5-amino-1, 3, 4-thiadiazole-2-thiol and its cu(ii) metal complex

Abstract

The Schiff base 1-(6-(1-((5-mercapto-1-3-thiodial-2-yl) imino) ethyl) pyridine-2-yl) ethanone (MTIEPE) was synthesized by condensation of 2, 6-diacetylpyridine and 5-amno-1, 3, 4-thiadiazole -2-thiol in ethanol using microwave method of synthesis. Cu(II) complex of MTIEPE was synthesized by refluxing the solution of the CuSO4.5H2O and the ligand in the ethanol in 1:1 molar ratio and the progress of the reaction was monitored using TLC. The ligand and Cu(II) complex were characterized using IR,NMR, and molar conductance. From the observed data it was concluded that the formula of the Cu(II) complex of MTIEPE ligand is CuOSO3 with octahedral geometry. Finally the antibacterial study of the Ligand MTIEPE and its copper (II) complex was carried out by disc diffusion method on selective bacteria. The complex showed greater antibacterial activity than the reference antibiotic, gentamycine, towards Staphylococcus aureus among the tested bacteria. Thus, with further investigation and exploitation this copper (II) complex can be used as antibacterial drugs for the treatment of infections caused by this bacterium.