Synthesis, characterization and biological activity of Ni (II) Schiff base complex derived from quinoxaline and ethylenediamine

Abstract

Schiff’s bases ligand are flexible and synthesized from condensation of primary amines and carbonyl groups. Metal complexes of Schiff bases derived from quinoxaline derivatives have played a central role in the development of new drug for medicinal chemistry. Numerous transitional metal complex of Schiff base ligand have been investigated scientifically for antimicrobial activity but still there are anti drug resistant of anti bacterial disease. Hence, a precursor Schiff base ligand was prepared by condensation of quinoxaline and ethylenediamine. The Ni- complex was synthesized by template method by condensation of Schiff base ligand, ethylenediamine and nickel salt. The result was characterized by different physicochemical studies such as elemental analysis, magnetic susceptibility, molar conductance measurement, UV-Visible, IR, 1H, 13C-NMR spectral studies. The molar conductance measurements of the complexes indicate their non-electrolytic nature. The electronic absorption spectra and magnetic data revealed the existence of an octahedral geometry for Ni-complex. The ligand and its Ni-complex were tested for antimicrobial activity against bacteria (E.faecalis and H.pylori). The results indicated that the ligand and its Ni-complex showed good activity against bacteria. The Ni-complex was more active than standard drug and ligand against Enterococcus faecalis but less active against H.pyoric bacteria than ligand and standard drug. The new Ni-complex synthesized was a good activity for gram positive bacteria. From this point of view, it was interest to synthesize and characterize Ni-complex with quinoxaline derivatives used for antimicrobial properties.