Anemia and its assiociation with helicobacter pylori infection among adult dyspeptic patients attending wachemo university nigist elein mohammad memorial referral hospital: hosanna, southwest Ethiopia

Abstract

Background: Anemia is a public health problem worldwide and also associated with H. pylori infection. Determining prevalence of anemia and its association with H. pylori infection is important to develop evidence based decision and intervention strategies. The magnitude of anemia and its association with H. pylori infection is not well known in this study area. Objectives: To determine prevalence of anemia and its association with H. pylori infection among adult dyspeptic patients attending Wachemo University Nigist Elein Mohammad Memorial Referral Hospital from January 8,2019 to April 1,2019; Hosanna, southwest Ethiopia. Method: A cross sectional study was conducted involving 362 consecutive adult dyspeptic patients who came to the Hospital during the study period. Socio-demographic, clinical and other related data were collected by structured questionnaire. Four milliliter of venous blood sample was collected for hematological parameters analysis and blood film preparation. Stool sample was collected to detect H. pylori antigen and intestinal parasite. Data were analyzed by SPSS version 21. Frequency table, graph and descriptive summaries were used to describe variables. Independent sample T-test, bivarate and multivariate logistic regression analysis were performed. In this study p<0.05 was considered as statistically significant. Results: The overall prevalence of anemia among dyspeptic patients was 24.3% (95%CI: 19.9, 28.7). Among H. pylori infected participants 29.2% were anemic, of which 69.2% had mild anemia and 63.5% had normocytic normochromic anemia. Rural residence (AOR: 1.9, 95%CI: (1.1, 3.3), H. pylori infection (AOR: 1.77, 95%CI: (1.05, 2.98) and intestinal parasitic infection (AOR: 2.14, 95%CI: (1.14, 4.03) were significantly associated with anemia. The mean (SD) values of HGB, RBC, HCT, MCV, MCH, MCHC and RDW were significantly different between H. pylori positive and negative participants. Conclusion: The prevalence of anemia in this study indicated that it is a moderate public health problem. Rural residence, H. pylori and intestinal parasitic infection were significantly associated with anemia. The findings of this study should be taken into account for prevention and control of anemia among dyspeptic adults.