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First report on blaNDM-1-producing Acinetobacter baumannii in three clinical isolates from Ethiopia

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dc.contributor.author Michael Pritsch
dc.contributor.author Ahmed Zeynudin
dc.contributor.author Maxim Messere, etal
dc.date.accessioned 2020-12-12T07:06:40Z
dc.date.available 2020-12-12T07:06:40Z
dc.date.issued 2017
dc.identifier.uri http://10.140.5.162//handle/123456789/3153
dc.description.abstract Background: Multidrug-resistant Gram-negative bacterial infections are recognized as one of the major threats to global health. In this study, we describe for the first time blaNDM-1 gene carrying organisms from Ethiopia consisting of three Acinetobacter baumannii isolates from patients in Jimma. Methods: Besides phenotypic antimicrobial susceptibility testing, molecular strain typing and sequencing was performed to describe the phylogenetic relation of the Ethiopian isolates in detail in relation to published isolates from all over the globe. Results and discussion: Three multi-resistant, blaNDM-1-positive Acinetobacter baumannii isolates, most likely a local clonal diffusion, were isolated. Two of the three isolates described within this study were untreatable with the locally available antimicrobials and were only susceptible to polymyxin B and amikacin. The genome sequences confirmed the isolates to be distinct from the outbreak strains reported from Kenya, the only other characterized blaNDM-1 positive Acinetobacter baumannii strains in East Africa so far. Up to date, no other bacterial species were found to harbour the gene cassette in Jimma and conjugation to E. coli was not successful under laboratory conditions. However, natural transmission to other bacteria seems likely, given the evident lack of hygienic precautions due to limited resource settings. Conclusions: The detected isolates could solely be the tip of the iceberg regarding the presence of NDM-1 producing organisms in the region, as only a limited number of bacterial isolates were evaluated so far and until recently, susceptibility testing and isolation of bacteria could hardly be performed in clinical patient care. These multi-drug resistant organisms pose a serious threat to antimicrobial treatments in Jimma, Ethiopia. en_US
dc.language.iso en en_US
dc.subject NDM-1 en_US
dc.subject New Delhi metallo-beta-lactamase en_US
dc.subject Acinetobacter baumannii en_US
dc.subject Carbapenemase en_US
dc.subject Ethiopia en_US
dc.subject EastAfrica en_US
dc.title First report on blaNDM-1-producing Acinetobacter baumannii in three clinical isolates from Ethiopia en_US
dc.type Thesis en_US


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