Prevalence of leukemia among patients who have abnormal hematological parameters in Jimma Medical Center(JMC) from January 1 to April 30 2019

Abstract

Background; Leukaemia is a heterogeneous group of haemopoietic cancers that comprise a number of diverse and biologically distinct subgroups. It is a global issue which addresses all regions of the world. Overall, these hematological cancers represent the 11th and 10th most frequent cause of cancer occurrence and death worldwide respectively. In Ethiopia, there is no adequate data regarding the current status on its prevalence and associated factors. Objective; This study was aimed to determine the prevalence of leukemia among patients who have abnormal hematological parameters in Jimma Medical Center from January 1 to April 30 2019 Methodology; A cross-sectional study was conducted among patients who have abnormal hematological parameters in Jimma Medical Center from January 1 to April 30, 2019. A consecutive sampling method was used. Ethical clearance was obtained from Jimma University institutional review board and consent from the study subjects or their attendants or guardians. Sociodemographic data was collected by using structured and pretested questionnaire. A total of 332 patients with abnormal hematological parameters were included and their CBC parameters as well as peripheral blood morphology and Bone marrow aspiration with Wright’s stain and cyochemistry study with Sudan black B stain was performed. data was entered with Epidata v4.4.31 and Descriptive statistics for theprevalence of leukemia was analyzed with IBM SPSS v25. Results and Conclusion; A total of 332 patients were studied. The overall prevalence of leukemia was 9.3% while prevalence by type of leukemia was AML = 3.6%, ALL=2.7%, CML=1.8% while CLL, MDS and undifferentiated Leukemia had a prevalence of 0.6% and 0.3% respectively. The prevalence of leukemia is significant amount that needs further investigations in regard to the associated factors and predictors