Serum lipid profile and uric acid comparsion among Rheumatoid arthritis patients and apparently health Controls at worabe compherensive specialized Hospital, worabe, southern ethiopia

Abstract

Background: Rheumatoid arthritis is a chronic autoimmune condition that mostly damages joints. Warm, swollen, and painful joints are frequently the result, especially in the hands and wrists. Due to a higher risk of cardiovascular disease, people with rheumatoid arthritis have higher rates of morbidity and death than the general population. An invivo experiment demonstrated that uric acid has a potent ability as a proinflammatory molecule derived from dying cells and These evidences suggest the possibility that uric acid could contribute to systemic inflammatory conditions such as rheumatoid arthritis. Objective: To compare serum lipid profile and uric acid among rheumatoid arthritis patients and apparently health individual controls at Worabe comprehensive specialized hospital from December 1, 2021, to April 1, 2022. Material and Methods: An institution-based Comparative cross-sectional study design was carried out to compare serum lipid profile and uric acid among patients with rheumatoid arthritis and apparently healthy individuals at worabe comprehensive specialized hospital. A total of 228 Study subjects were included and selected by using convenient sampling techniques. Questionnaires were used to collect socio-demographic and clinical data. Anthropometric data were collected by an experienced nurse. A 5mL blood specimen was collected on a serum separator tube. The lipid profile and uric acid were analyzed by the Roche Cobas c 311 automated clinical chemistry analyzer. The Statistical Package for Social Science (SPSS) version 25 software was used to analyze the data. Results: The results of our study showed that there was significant elevation of the median and interquartile range of TC, TG, LDL-C, TC/HDL-C, LDL-C/HDL and SUA but a lower value of HDL-C was seen among rheumatoid arthritis patients than controls (P value < 0.05). SUA had a significant negative correlation with HDL-C (ρ= -0.449), but a significant positive correlation with TC (ρ= 0.692), TG (ρ= 0.555), LDL-C (ρ= 0.695), and TC/HDL-C (ρ= 0.621). Conclusion: The result of this study showed that significant elevation of TC, TG, LDL-C, TC/HDL, LDL/HDL and SUA but, lowered value of HDL-C was seen among RA patients than controls. So, it is possible to conclude that dyslipidemia was seen among RA patients than controls