Assessment of liver and metabolic disorder and associated factors among tuberculosis patients attending at jimma town public health facilities, southwest Ethiopia

Abstract

Background: Most developing countries are still suffering from diffrent infectious disease,such as tuberculosis. Patients infected with tuberculosis are more likely susceptible to metabolic disorders and liver diseases that cause,which may results non communicable disease like diabetes mellitus and derangementof hepatic biomarkers. The elevations of liver enzymes and hyperglycemia are the primary indicator of hepatic and metabolic abnormalities .However; thus, regular updated data on the studies of liver and selected metabolic disorder using liver enzymes and metabolic tests among TB patients in Ethiopia important to reduce tuberculosis associated complications,morbidities and mortalities. Objectives: to assess liver and metabolic disorder and associated risk factors among patients who are on anti TB Treatment at Jimma town public health facilities, South west Ethiopia from October 2020 to February 2021. Methods and materials: It was Institutional-based cross-sectional studyconducted in Jimma.Convenient sampling technique was carried out to select 179TB patients attending at Jimma town public health facilities.The socio-demographic and other related clinical data were collected using the structured questionnaires and by reviewing patient’s medical record . Five ml venous blood was collected from participants aftereach participants stay on fastingovernight. Then fasting blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma glutamyl-transferase (GGT) were measured using Humastar 100 automated analyzer.Data were analyzed using statistical package for social science version 26, while logistic regression was used to assess associated factors. Result: Among 179 TB patients, 45(25.1%)of them were found to have one or more elevated liver enzymes. The prevalence of elevated serum ALT, AST, ALP and GGT was 18.4%, 17.3%, 3.9%, and 5.6% respectively and prevalence of hyperglycemia was 7.3%. In this study, intensive phase of anti TB treatment and government employed were found significant predictors of elevated serum ALT in TB patients (P< 0.05). Conclusion:Inthis study high prevalence of hyperglycemia and one or more liver enzymes increments in TB patients was found. This result indicates TB patients were more susceptible toliver enzyme disturbance .Routine assessment of serum liver enzymesand blood sugar might be beneficial for TB patients to control and follow up of liver dysfunction and metabolic disorder.Furthermore, researches that clarify causative factors and mechanisms of liver enzyme increment and metabolic disturbance in TB patients should be conducted.