Assessment of lipid profile, uric acid, alanine aminotransferase, and Risk factors in helicobacter pylori-positive subjects in jigjiga University sultan sheik hassan yabare referral hospital

Abstract

Background: Helicobacter pylori (H. pylori) colonization of the stomach produces chronic inflammation of the stomach wall, which might alter various clinical chemistry parameters in the patient. According to a study, gastrointestinal infection with H. pylori alters the blood lipid profile, which includes cholesterol, Triglyceride, Low density lipoprotein cholesterol, and High density lipoprotein cholesterol. However, there is a limitation in the consistency of the study findings, and Moreover the impact of H. pylori on alanine amino transferase (ALT) and Uric acid has not been well explored. Objectives: Assessment of lipid profile, uric acid, alanine aminotransferase, and risk factors in helicobacter pylori-positive subjects in Jigjiga University Sultan Sheik Hassan Yabare Referral Hospital, Somali, Eastern Ethiopia, from June 01 to January 30, 2023. Methods: A comparative cross-sectional study was conducted on 304 (152 H. pylori positive patients and 152 controls) study participants selected by consecutive sampling technique. Socio- demographic, life style, and clinical data were collected by trained personnel using a structured questionnaire and checklist. Clinical chemistry parameters such as ALT, Uric acid, and lipid profile were determined using Biosystems A25 (Costa Brava, Spain) analyzers from serum spacemen. All phase of quality assurance was maintained. Independent t-test, Mann–Whitney U- test, correlation, and logistic regression were used during data analysis. P-value <0.05 was considered statistically significant. Result: The current study found that ALT, URIC ACID, TC, and TG were significantly higher in H. pylori-positive patients as compared to the control group (P<0.05). On the other hand, the mean HDL-C was significantly lower in H. pylori-positive patients than the control group (P=<0.005). Sex (AOR = 1.7, 95 % CI = 1.04- 2.74), Eating food on one plate (AOR= 3.5, 95% CI = 1.2-13.2), and Not washing hands after toilet (AOR = 0.114, 95% CI= 0.013-0.957) were significantly associated with H. Pylori. Conclusion: This study showed a statistically significant variation in some clinical chemistry parameters of H. pylori patients compared to the control group. Therefore, routine screening of clinical chemistry parameters should be considered for proper management of H. pylori-positive patients