Jimma University Open access Institutional Repository

Prevalence of streptococcus agalactiae and antimicrobial Susceptibility of isolate among pregnant women Attending antenatal care at jimma university medical Center, southwest Ethiopia

Show simple item record

dc.contributor.author Asresahegn Awulo
dc.contributor.author Zewdineh Sahlemariam
dc.contributor.author Rahel Tamrat
dc.date.accessioned 2025-10-14T07:49:28Z
dc.date.available 2025-10-14T07:49:28Z
dc.date.issued 2025-05
dc.identifier.uri https://repository.ju.edu.et//handle/123456789/9934
dc.description.abstract Background: Streptococcus agalactiae (Group B Streptococcus, GBS) is a major cause of meningitis and sepsis in newborns and is the primary cause of perinatal bacterial diseases in pregnant women. It leads to significant morbidity and mortality for both mothers and infants. This issue is particularly concerning in Ethiopia, especially in the current study area, where it has not been adequately addressed. Objectives: To determine the colonization rate, antibacterial susceptibility isolates, and associated factors of GBS among pregnant women attending antenatal care at JUMC. Methods: A hospital-based cross-sectional study was conducted at Jimma University Medical Center from August 1 to November 30, 2024. Recto-vaginal swab samples were collected by brushing the lower vagina and rectum with a sterile cotton swab and inoculated onto 5% sheep blood agar. Biochemical testing was performed alongside antimicrobial susceptibility testing using the Kirby-Bauer method. Data analysis was conducted using EpiData version 3.1 and SPSS version 25. Logistic regression assessed the relationship between explanatory and outcome variables, with significance set at p < 0.05. Results: The overall colonization rate of GBS among pregnant women attending antenatal care was 10.2% (23/225).GBS colonization was significantly associated with history of premature rupture of the membrane(AOR=3.187, 95% CI= 1.052-9.654). And history of Urinary tract infection (AOR=4.267, 95% CI= 1.556 -11.698). The majority of GBS isolates were sensitive to vancomycin (100%), ampicillin (93.1%), and penicillin (95.7%). In contrast, the GBS isolates were found resistant to ceftriaxone, tetracycline ciprofloxacin, clindamycin, and Azithromycin with a rate of 21.7%, 91.3%, 34.8%, 26.1%, and 21.7% respectively. Conclusions: The colonization rate of Group B Streptococcus (GBS) among pregnant women at JUMC was low, with most isolates sensitive to vancomycin, ampicillin, and penicillin G. However, many isolates showed resistance to commonly used antibiotics. This highlights the need for routine GBS screening in pregnant women and efforts to combat antimicrobial resistance. en_US
dc.language.iso en_US en_US
dc.subject Group B streptococci en_US
dc.subject antimicrobial susceptibility testing en_US
dc.subject Pregnant women en_US
dc.subject Recto-vaginal colonization en_US
dc.subject JUMC en_US
dc.title Prevalence of streptococcus agalactiae and antimicrobial Susceptibility of isolate among pregnant women Attending antenatal care at jimma university medical Center, southwest Ethiopia en_US
dc.type Thesis en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search IR


Browse

My Account