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Bacterial Profile and Antimicrobial Susceptibility Patterns among Neonate Diagnosed with Sepsis at Jimma Medical Center, Southwest Ethiopia

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dc.contributor.author Didimos Gezahegn
dc.contributor.author Getenet Beyene
dc.contributor.author Rahel Tamirat
dc.contributor.author Gemeda Abebe
dc.date.accessioned 2025-10-14T07:56:00Z
dc.date.available 2025-10-14T07:56:00Z
dc.date.issued 2025-06
dc.identifier.uri https://repository.ju.edu.et//handle/123456789/9935
dc.description.abstract Background: Neonatal sepsis (NS) is a potentially deadly and life-threatening condition that arises from an unregulated host response to a systemic infection within the first 28 days of life in the newborn. Understanding the bacterial profiles and antibiotic susceptibility patterns causing neonatal sepsis is crucial for guiding appropriate treatment, improving patient outcomes, and combating the emergence of antibiotic resistance. The study aimed at determining the Bacterial Profile and Antimicrobial Susceptibility Patterns among Neonate Diagnosed with Sepsis at Jimma Medical Center from April 2024 to September 2024. Methods: Hospital-based cross-sectional study design was conducted at JUMC from April 2024 to September 30th, 2024. Blood culture was performed for a total of 342 septicemia suspected patients at NICU wards. Bacterial isolation and identification were made using standard bacteriological methods. Antimicrobial susceptibility was done by disk diffusion method. Extended spectrum beta lactamase (ESBL) and MDR production were determined among gram negative bacteria (GNB). Socio-demographic data of study participants was collected using a structured questionnaire by interviewing the parents of neonates in a face-to-face approach. and Data was managed using STATA version 16.0 and WHONET 2024 software Resuls:: Of 342 participants, 40% (95% CI: 35.1, 45.6) of culture-confirmed sepsis was. Gram negative bacteria accounted for 73.1% (95% CI: 65.6, 80.7) of the cases, ESBL-producing isolates accounted for 70% (95% CI: 69.8, 72.8) cases, Finally, multidrug-resistant bacteria were detected in 88.4% (95% CI: 81.8, 93.0) of the cases, with Extended beta lactamase (ESBL) producing gram-negative isolates contributed 55.7% (95% CI: 46.5, 64.6), followed by non ESBL-producing gram-negatives at 25.4% (95% CI: 18.0, 34.1). Conclusion: - The prevalence rate of septicemia suspected patients was significantly high. GNB were the predominant isolates and majority of isolates were MDR pathogens. The majority (69.3%) of gram negative bacteria were ESBL producers. Recommendations: Better diagnostic capability, enhanced infection prevention and antibiotic stewardship programs (ASP) are necessary to reduce the incidence of septicemia and AMR en_US
dc.language.iso en_US en_US
dc.subject Neonatal sepsis en_US
dc.subject Bacterial profile en_US
dc.subject ESBL en_US
dc.subject Antimicrobial Susceptibility Pattern en_US
dc.title Bacterial Profile and Antimicrobial Susceptibility Patterns among Neonate Diagnosed with Sepsis at Jimma Medical Center, Southwest Ethiopia en_US
dc.type Thesis en_US


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