Jimma University Open access Institutional Repository

Clinical profile and outcome of patients diagnosed with Guillian barre syndrome at jumc

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dc.contributor.author Addis Ketema
dc.contributor.author Menur Abrar
dc.date.accessioned 2025-10-14T08:19:30Z
dc.date.available 2025-10-14T08:19:30Z
dc.date.issued 2025-02
dc.identifier.uri https://repository.ju.edu.et//handle/123456789/9937
dc.description.abstract Background: Guillain-Barré Syndrome (GBS) is a severe neurological disorder with significant morbidity and mortality. This study aimed to assess the clinical characteristics, epidemiology, and outcomes of GBS patients at Jimma Medical Center (JMC) in Ethiopia. Methods: A retrospective and prospective study was conducted on GBS patients admitted to JMC between 2017 and 2024. Data on socio-demographics, clinical presentation, diagnostic findings, management, and outcomes were analyzed using descriptive statistics and survival analysis. Results: A total of 75 GBS patients were admitted, with a median age of 31 years (IQR: 24–42), and 66.7% were male. Most patients (76%) resided in rural areas. Antecedent events were identified in 56%, primarily upper respiratory tract infections (29.3%). The median time from symptom onset to admission was 5 days (IQR: 3–7). Ascending muscle weakness (85.3%) was the most common presentation, and 29.3% had respiratory muscle involvement. ICU admission was required in 50.7% of cases, and 25.3% needed mechanical ventilation. Only 2.7% received IV immunoglobulin, while the majority received supportive care. The in-hospital mortality rate was 18.7%, with significantly lower survival among mechanically ventilated patients (p = 0.021). Conclusions: GBS imposes a substantial burden at JMC, with high ICU admission and mortality rates. Limited access to immunotherapy and advanced care contributes to poor outcomes. Early diagnosis, improved supportive care, and increased awareness are essential for better management of GBS in Ethiopia and similar low-resource settings en_US
dc.language.iso en_US en_US
dc.subject Guillain-Barré Syndrome en_US
dc.subject respiratory failure en_US
dc.subject mortality en_US
dc.subject Jimma Medical Center en_US
dc.subject Ethiopia en_US
dc.title Clinical profile and outcome of patients diagnosed with Guillian barre syndrome at jumc en_US
dc.type Thesis en_US


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