Abstract:
Dyslipidemia is a condition in which total cholesterol ≥200mg/dl, triglycerides ≥ 150mg/dl, low density lipoprotein cholesterol ≥130mg/dl, and/ or high-density lipoprotein cholesterol ≤ 40mg/dl. Colonization of the stomach by Helicobacter pylori causes chronic inflammation of the stomach wall which can change some biochemical parameters. On the association of Helicobacter pylori infection and its contributions to change in serum lipid profile, different studies reported inconsistent outcomes. Objective: To assess prevalence of dyslipidemia and associated factors among patients suspected for gastritis at outpatient department of Jimma University medical center, Jimma, Ethiopia, from January 03 to April 05, 2019. Method: A Hospital based cross- sectional study was conducted at Jimma University medical center on 369 gastritis suspected patients. The study subjects were selected by convenient sampling technique. Socio-demographic data were collected by structured questionnaire. 5ml of blood was collected from an overnight fasting subject. Data were edited, coded, and entered into Epidata version 3.1 and exported to statistical package for social sciences version 25 for analysis. Bivariate analysis was used to screen those variables which were candidates for multivariate analysis. Result: From the total study subjects, 286 (77.5%) had at least one abnormality in lipid profile and 151/173(87.2%) of H. pylori positive patient had at least one abnormality in lipid profile. Our study demonstrated that there was significant increase of mean ± SD of TC, TG, and LDL-C in H. pylori positive patients than H. pylori negative patients (P-value < 0.05). After adjusting for traditional dyslipidemia risk factors, H. pylori infection was an independent predictor of dyslipidemia (AOR 2.628, 95%CI 1.477- 4.678, P = 0.001). Conclusion and Recommendations: An increase in prevalence of dyslipidemia among H. pylori positive patients indicates H. pylori infected patients have a possibility of modified lipid profile, there for assessment of lipid profile in H. pylori infected patient is recommended.
