Abstract:
Schiff’s bases ligand are flexible and synthesized from condensation of primary amines and
carbonyl groups. Metal complexes of Schiff bases derived from quinoxaline derivatives have
played a central role in the development of new drug for medicinal chemistry. Numerous
transitional metal complex of Schiff base ligand have been investigated scientifically for
antimicrobial activity but still there are anti drug resistant of anti bacterial disease. Hence, a
precursor Schiff base ligand was prepared by condensation of quinoxaline and
ethylenediamine. The Ni- complex was synthesized by template method by condensation of
Schiff base ligand, ethylenediamine and nickel salt. The result was characterized by different
physicochemical studies such as elemental analysis, magnetic susceptibility, molar conductance
measurement, UV-Visible, IR, 1H, 13C-NMR spectral studies. The molar conductance
measurements of the complexes indicate their non-electrolytic nature. The electronic absorption
spectra and magnetic data revealed the existence of an octahedral geometry for Ni-complex.
The ligand and its Ni-complex were tested for antimicrobial activity against bacteria (E.faecalis
and H.pylori). The results indicated that the ligand and its Ni-complex showed good activity
against bacteria. The Ni-complex was more active than standard drug and ligand against
Enterococcus faecalis but less active against H.pyoric bacteria than ligand and standard drug.
The new Ni-complex synthesized was a good activity for gram positive bacteria. From this
point of view, it was interest to synthesize and characterize Ni-complex with quinoxaline
derivatives used for antimicrobial properties.
