Abstract:
Malaria is a major contributor to the global disease burden and a significant impediment
to socio-economic development in resource-poor countries. In contrast to improved
trends of malaria morbidity and mortality in some parts of the world, malaria has re‐
mained a life threatening disease in many other regions including East Africa because of
factors such as weak health systems, growing drug and insecticide resistance, ecological
change, climate anomalies, socio-economic factors and changes in land use patterns. On‐
going malaria vector control strategies rely mainly on the use of indoor residual spraying
(IRS) and insecticide treated nets (ITNs) which are the primary intervention strategies to
reduce malaria burden. The current success in reducing malaria related morbidity and
mortality has led to the optimism that elimination of the disease as a public health prob‐
lem may be a realistic objective. Efforts during the last decades enabled access to ITNs in
sub-Saharan Africa protecting millions of people at risk of malaria. The number of coun‐
tries that employed IRS as a vector control strategy increased almost by two fold and the
percentage of households owing at least one ITN in sub-Saharan Africa is estimated to
increase from time to time. Currently, all ITNs are treated with pyrethroids while IRS de‐
pends on pyrethroids, DDT and recently on carbamates. Despite IRS and ITNs are known
in reducing malaria incidence, insecticide resistance in malaria vectors threatens the suc‐
cess of malaria control program. Resistance to insecticides has occurred in most arthro‐
pod vectors with different mechanisms. If the current trends of increased insecticide
resistance continue, it may jeopardise the efficacy of current vector control tools. Given
the limited choice of available insecticides, i.e., only 12 insecticides belonging to 4 classes
of insecticides (organochlorines, organophosphates, pyrethroids and carbamates), resist‐
ance to these insecticides has become a limiting factor for current efforts to sustain con‐
trol. Currently, no other insecticide class with similar efficacy has been approved by
WHOPES. The development of insecticide resistance in malaria vectors has been attribut‐
ed to the prolonged use of insecticides for IRS and high coverage of ITNs/LLINs. The re‐
cent use of pyrethroids for indoor residual spraying is likely to have enhanced the
selection pressure for insecticide resistance alleles among East African vector popula‐
tions. Moreover, mosquitoes breeding in agricultural habitats are exposed to sub lethal
© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons
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and reproduction in any medium, provided the original work is properly cited.doses of pesticides used in agriculture. Since currently recommended insecticides for IRS
or ITNs were developed with similar active ingredients of pesticides used for agricultural
pest control, their extensive and widespread use to boost agricultural productivity is be‐
lieved to foster insecticide resistance in mosquito populations. There is strong evidence
on the emergence of resistance to DDT and pyrethroids in the major malaria vectors in
East Africa however, current information on resistance status of the malaria vectors in
different areas of the sub-region is scarce. Genes conferring resistance to malaria vectors,
including kdr, super kdr and acetylcholinesterase mutations and metabolic resistance are
not mapped. The frequency and spatial distribution of East and West African kdr muta‐
tions and their association with the phenotypic resistance in East Africa is less under‐
stood. The bioassay results after WHO diagnostic tests in different East African malaria
vector populations against insecticides used in public health is not well documented. In
conclusion, planning and implementing insecticide resistance monitoring and manage‐
ment strategy should be part of the vector control program either for pre-emptive action
without waiting for the development of resistance or to slowdown the spread of resist‐
ance in malaria vectors in the sub-region.