Abstract:
Background: - Type 2 Diabetes mellitus (T2DM) is associated with cardiovascular
complications, of which metabolic syndrome (Mets) plays a prominent role. The metabolic
syndrome is a cluster of cardiovascular risk factors that is characterized by central obesity,
insulin resistance, dyslipidemia and hypertension. Hyperuricemia is a condition in which the
subject has increased serum uric acid levels. Studies have noted that an elevated level of uric
acid predicts the development of diabetes, obesity, hypertension and metabolic syndrome.
Methods: - Institution based cross sectional study was conducted in Hawassa Comprehensive
Specialized Hospital medicine department from February to June 2017. A diabetes mellitus
patient who visited the hospital during the study period and fulfilled the inclusion criteria was
selected by using simple random sampling technique. A total of 314 subjects were included in
the study. The data was collected by nurses who had previous data collection experience using
standardized quastionnaeries. About 5 milliliters (ml) of venous blood sample was drawn from
each study participant after overnight fasting. The collected data was entered in to Epidata and
analyzed by using SPSS version 20 software. Bivariate and Multivariate Logistic Regression
analysis (if p>0.2 for Bivariate) was used to determine the association between explanatory
variables and the outcome variable. Statistical significance was declared at P value<0.05.
Result: - The prevalence of hyperuricemia among the study participants was 33.8% and the
prevalence of metabolic syndrome was 70.1%. Hyperuricemia was significantly associated with
Metabolic syndrome (P=0.004).Hyperuricemia was strongly correlated with Triglycerides
(P<0.001), Diastolic blood pressure (p=0.006), systolic blood pressure (p<0.0001), and Waist
circumference (p<0.0001).
Conclusion:-The prevalence of hyperuricemia and metabolic syndrome among T2DM was high
and hyperuricemia was associated with metabolic syndrome. Hyperuricemia also correlated with
some of the components of metabolic syndrome.Recommendation: T2DM better be checked for their uric acid level and further research should
be conducted with better study design.
