Abstract:
Background:. Oral pre-exposure prophylaxis (Pr EP) of HIV infection is the use of antiretroviral (ARV)
drugs by people who do not have HIV infection in order to prevent the acquisition of HIV among that
population group with substantial risk. The medication proven safe and effective currently approved for
Pre ep in healthy adults at risk of acquiring HIV infection is the fixed-dose combination of Tenofovir
Disoproxil Fumarate (TDF) and Emtricitabine (FTC) in a single daily dose.
Objective: To identify determinants of willingness to use pre-exposure prophylaxis for HIV prevention
among female sex workers in Jimma town, south west Ethiopia, 2022
Methods and materials: A facility-based case control study was conducted on 328 female sex workers
from which 109 were case and 228 were control. The study population was sero-negative female sex
workers visiting health facility to receive service packages designed for female sex workers. This study
was conducted Jimma town from April 15 to July 20, 23022. The questionnaire was developed based on
predetermined variables after reviewing relevant references. Data were entered into EPI-data version 4.6.
In addition, the data to SPSS statistical package version 23.0 for analysis. Binary logistic regression
analysis was used to identify the determinant of willingness. All determinants having p-value < 0.25 in the
binary analysis were included in multivariate logistic regression models. Finally, variables with odd ratio
greater than 1 and with p<0.05 were considered statically significant.
Results: Willingness to use pre exposure prophylaxis (PrEP) was associated with having tested for HIV in
the last 3months with AOR. 6.65(95% CI 2.27, 19.51). Not having perceived stigma towards, taking pre
exposure prophylaxis,, with {AOR 53.04 and 95% CI (10.10, 246.96)}. Female sex workers with no fear
of drug side effect were more likely to use pre ep with,{ AOR of 6.57(95%CI 1.81, 23.88)} and female
sex workers who have good family relation were more likely to have willingness to use with AOR of
19.17(95% CI 5.07,72.50).
Conclusion and recommendation: In this study fear of drug side effect, family relation, perceived
stigma and having HIV test in the last three months were significantly affect the willingness of female sex
workers (FSWs) to use pre-exposure. Based on the finding of this study it is recommended that health
facilities should provide health education for female sex workers on drug side effects, benefit of frequent
HIV testing, and promote frequent HIV testing as recommended by world health organization. Women,
child affair offices, and other faith-based organizations should work on building
