Evaluation of Metabolic Biomarkers and Associated Factors Among Benign Prostatic Hyperplasia Patients at Jimma University Medical Center, Southwest Ethiopia

Abstract

Background: Benign prostatic hyperplasia is a common cause of lower urinary tract obstruction in older adults, attributed to the growth of smooth muscle cells in the prostatic transition zone. The ma jor risk factor for Benign Prostatic Hyperplasia is metabolic syndrome, despite the high burden of metabolic syndrome in Ethiopia, not much study has been done on its association with benign pros tatic hyperplasia Objective: This study aims to determine selected metabolic biomarkers in individuals diagnosed with BPH attending Jimma University Medical Center Methods and Materials: Hospital-based cross-sectional study was conducted at Jimma University medical center among 158 consecutive male BPH patients from January 15 to April 15. A structured questionnaire was used to collect socio-demographic characteristics. Data were collected by trained clinical nurses. A 5ml blood sample was drawn and analyzed using a Cobas 6000 chemistry analyzer by a laboratory technologist and under the close supervision of a principal investigator. All anthro pometric, and blood pressure measurements were taken according to their specific principles with appropriate measurement devices. Data was entered into Epi-data version 4.6.0.6 and analyzed using a statistical package for social sciences version 26. National Cholesterol Education Program Adult Treatment Panel criteria were used to determine the occurrence of metabolic syndrome. Logistic re gression was used to assess factors associated with metabolic syndrome. Result: The overall prevalence of metabolic syndrome among patients with BPH patients attending JUMC was 38.6% (0.31,0.46). Factors such as age AOR: 3.43 (95% CI:1.3, 9), urban residence AOR:3.35 (95% CI: 1.35, 8.30), total cholesterol AOR:3.20 (95% CI:1.27, 8.06), high LDL (130mg/dl) AOR:3.54 (95% CI:1.08, 11.56), WHR >0.9 AOR: 5.07 (95% CI:2.15, 11.98), BMI≥25kg/m2 AOR: 3.47 (95% CI: 1.44,8.32), and serum uric acid AOR: 3.21 (95% CI:1.02, 10.01) were significantly associated with metabolic syndrome. About 33.5% (95% CI: 0.26,0.40) of partici pants had prostate volumes ≥80ml. Obesity (WC>40inch) AOR:2.49 (95% CI:1.18,5.24) (HDL<40mg/dl), AOR:2.87 (95% CI:1.26,6.53), and (FBS≥100mg/dl) AOR:2.46 (95% CI:1.14,5.3) were significantly associated with increased prostate volume. Conclusion and recommendation: The prevalence of metabolic syndrome in Benign Prostate Hy perplasia patients was significantly high. There is a need to assess components of metabolic syn drome for the betterment of patient management to curtail further complications.