Abstract:
Since the prevalence of multi-drug resistance micro-organisms cause serious infectious disease
to be greatest health challenges in worldwide which are treated by antibiotics. Antibiotic
resistance leads to higher medical expenses, prolonged hospital stays, and increased mortality. In
addition, oxidative stress results in excessive production of free radicals causes serious chronic
disease like cancer, diabetes, stroke and heart disease. On the other side the unavailability of
clean water prompted from industrial application of methylene blue dye is one of the significant
burdens for human health and environment. In these regard, metal oxide nano-based drugs and
nano catalyst are possible alternatives to overcome the aforementioned problems. There are
distinct physical and chemical methods of synthesis of nanoparticle usually uses non
biodegradable reducing agent and toxic organic solvent. Herein, noble phytochemical mediated
synthesis of silver doped copper oxide nanocomposite is a simple, cost effective, non-toxic, and
eco-friendly than commonly used methods. As a result, this study was aimed to synthesize Ag
CuO NCs via facile and cost effective phytochemical assisted co-precipitation method by
mixing of Cu (NO3)2.3H2O and AgNO3, using solanum tuberosum peel extract as reducing agent.
The synthesized NPs were characterized by UV−vis, FT-IR, XRD and SEM. The UV−vis
analysis showed a red shift after silver doping, indicating a decrease in the optical band gap
values from 2.96 to 2.64 eV. FT-IR spectroscopy analysis confirmed the involvement of
phytochemicals in stabilization and reduction of the NCs. XRD studies showed the purity and
crystalline structure of CuO NPs and Ag-CuO NCs with crystallite sizes of 15 and 18 nm
respectively. SEM result shows a spherical and mixture of spherical with rod-like shape for NPs
and NCs respectively. The Ag–CuO NCs demonstrated remarkable inhibitory activity against
S.aureus (26±0.53 mm) and E.coli (25±0.56 mm) at 100 mg/mL. Ag–CuO NCs exhibited
outstanding DPPH radical scavenging activity with a low IC50 value of 35.17μg/mL. Concerning
the environmental applications, the 5% Ag–CuO NCs displayed efficient photocatalytic activity
against MB dye degradation up to 97% with comparing to 88% of pure CuO NPs within 120
min. Furthermore, the findings of our investigation displayed 5%Ag–CuO NCs is remarkably
effective for bioremediation and environmental applications.
