Solanum tuberosum Peel Extract Mediated Synthesis of Copper Oxide Nano particle And Silver Doped Copper Oxide Nano composite And Evaluation of Their Antimicrobial, Antioxidant and Photo catalytic Degradation of Methylene Blue Dye

Abstract

Since the prevalence of multi-drug resistance micro-organisms cause serious infectious disease to be greatest health challenges in worldwide which are treated by antibiotics. Antibiotic resistance leads to higher medical expenses, prolonged hospital stays, and increased mortality. In addition, oxidative stress results in excessive production of free radicals causes serious chronic disease like cancer, diabetes, stroke and heart disease. On the other side the unavailability of clean water prompted from industrial application of methylene blue dye is one of the significant burdens for human health and environment. In these regard, metal oxide nano-based drugs and nano catalyst are possible alternatives to overcome the aforementioned problems. There are distinct physical and chemical methods of synthesis of nanoparticle usually uses non biodegradable reducing agent and toxic organic solvent. Herein, noble phytochemical mediated synthesis of silver doped copper oxide nanocomposite is a simple, cost effective, non-toxic, and eco-friendly than commonly used methods. As a result, this study was aimed to synthesize Ag CuO NCs via facile and cost effective phytochemical assisted co-precipitation method by mixing of Cu (NO3)2.3H2O and AgNO3, using solanum tuberosum peel extract as reducing agent. The synthesized NPs were characterized by UV−vis, FT-IR, XRD and SEM. The UV−vis analysis showed a red shift after silver doping, indicating a decrease in the optical band gap values from 2.96 to 2.64 eV. FT-IR spectroscopy analysis confirmed the involvement of phytochemicals in stabilization and reduction of the NCs. XRD studies showed the purity and crystalline structure of CuO NPs and Ag-CuO NCs with crystallite sizes of 15 and 18 nm respectively. SEM result shows a spherical and mixture of spherical with rod-like shape for NPs and NCs respectively. The Ag–CuO NCs demonstrated remarkable inhibitory activity against S.aureus (26±0.53 mm) and E.coli (25±0.56 mm) at 100 mg/mL. Ag–CuO NCs exhibited outstanding DPPH radical scavenging activity with a low IC50 value of 35.17μg/mL. Concerning the environmental applications, the 5% Ag–CuO NCs displayed efficient photocatalytic activity against MB dye degradation up to 97% with comparing to 88% of pure CuO NPs within 120 min. Furthermore, the findings of our investigation displayed 5%Ag–CuO NCs is remarkably effective for bioremediation and environmental applications.