Abstract:
Multi-drug resistance is a growing problem in the treatment of infectious diseases. The
widespread use of antibiotics has produced resistance for many human bacterial pathogens.
The advancement of nanotechnology, indicated bio-synthesis of nanoparticles supported on
medicinal plants have improved therapeutic capacity Silver nanoparticles. Medicinal plants
are parts of plant that have medicinal purposes. Preliminary phytochemical investigations
of Persicaria lapathiofolia crude extract has showed the presence of different secondary
metabolites as of flavonoids, Alkaloids and phenolic compounds. The main objectives of
this study is to synthesize, characterize and evaluate antimicrobial study of Persicaria
lapathifolia seed extract supported silver nanoparticles. The synthesized Silver
nanoparticles were characterized by UV-Vis, FT-IR spectroscopy, Powder XRD analysis,
and TEM images. The green synthesized Silver nanoparticles were characterized by color
change pattern, and the broad peak at 413 nm in the UV–Vis region. The observed surface
plasmon resonance suggested formation of small sized Silver nanoparticles. The color
change observed during preliminary phytochemical investigation and the FT-IR
spectroscopic analysis suggested flavonoids, phenols and Alkaloids are highly responsible
for reduction and stabilization of the synthesized silver nanoparticles. From the
crystallographic studies of XRD and images of TEM microscopic studies, the synthesized
Silver nanoparticles were polycrystalline in nature owing to 18.9 nm and spherical in shape.
Finally, the bio-assay test showed the highest antimicrobial activity of Silver nanoparticles
than plant extract against Escherichia coli from rest of bacterial strains as a result of
synergistic effect.
