Abstract:
Background: Rheumatoid arthritis is a chronic autoimmune condition that mostly damages
joints. Warm, swollen, and painful joints are frequently the result, especially in the hands and
wrists. Due to a higher risk of cardiovascular disease, people with rheumatoid arthritis have
higher rates of morbidity and death than the general population. An invivo experiment
demonstrated that uric acid has a potent ability as a proinflammatory molecule derived from
dying cells and These evidences suggest the possibility that uric acid could contribute to systemic
inflammatory conditions such as rheumatoid arthritis.
Objective: To compare serum lipid profile and uric acid among rheumatoid arthritis patients
and apparently health individual controls at Worabe comprehensive specialized hospital from
December 1, 2021, to April 1, 2022.
Material and Methods: An institution-based Comparative cross-sectional study design was
carried out to compare serum lipid profile and uric acid among patients with rheumatoid
arthritis and apparently healthy individuals at worabe comprehensive specialized hospital. A
total of 228 Study subjects were included and selected by using convenient sampling techniques.
Questionnaires were used to collect socio-demographic and clinical data. Anthropometric data
were collected by an experienced nurse. A 5mL blood specimen was collected on a serum
separator tube. The lipid profile and uric acid were analyzed by the Roche Cobas c 311
automated clinical chemistry analyzer. The Statistical Package for Social Science (SPSS) version
25 software was used to analyze the data.
Results: The results of our study showed that there was significant elevation of the median and
interquartile range of TC, TG, LDL-C, TC/HDL-C, LDL-C/HDL and SUA but a lower value of
HDL-C was seen among rheumatoid arthritis patients than controls (P value < 0.05). SUA had a
significant negative correlation with HDL-C (ρ= -0.449), but a significant positive correlation
with TC (ρ= 0.692), TG (ρ= 0.555), LDL-C (ρ= 0.695), and TC/HDL-C (ρ= 0.621).
Conclusion: The result of this study showed that significant elevation of TC, TG, LDL-C,
TC/HDL, LDL/HDL and SUA but, lowered value of HDL-C was seen among RA patients than
controls. So, it is possible to conclude that dyslipidemia was seen among RA patients than
controls
