Abstract:
Background: Helicobacter pylori (H. pylori) colonization of the stomach produces chronic
inflammation of the stomach wall, which might alter various clinical chemistry parameters in the
patient. According to a study, gastrointestinal infection with H. pylori alters the blood lipid
profile, which includes cholesterol, Triglyceride, Low density lipoprotein cholesterol, and High
density lipoprotein cholesterol. However, there is a limitation in the consistency of the study
findings, and Moreover the impact of H. pylori on alanine amino transferase (ALT) and Uric
acid has not been well explored.
Objectives: Assessment of lipid profile, uric acid, alanine aminotransferase, and risk factors in
helicobacter pylori-positive subjects in Jigjiga University Sultan Sheik Hassan Yabare Referral
Hospital, Somali, Eastern Ethiopia, from June 01 to January 30, 2023.
Methods: A comparative cross-sectional study was conducted on 304 (152 H. pylori positive
patients and 152 controls) study participants selected by consecutive sampling technique. Socio-
demographic, life style, and clinical data were collected by trained personnel using a structured
questionnaire and checklist. Clinical chemistry parameters such as ALT, Uric acid, and lipid
profile were determined using Biosystems A25 (Costa Brava, Spain) analyzers from serum
spacemen. All phase of quality assurance was maintained. Independent t-test, Mann–Whitney U-
test, correlation, and logistic regression were used during data analysis. P-value <0.05 was
considered statistically significant.
Result: The current study found that ALT, URIC ACID, TC, and TG were significantly higher in
H. pylori-positive patients as compared to the control group (P<0.05). On the other hand, the
mean HDL-C was significantly lower in H. pylori-positive patients than the control group
(P=<0.005). Sex (AOR = 1.7, 95 % CI = 1.04- 2.74), Eating food on one plate (AOR= 3.5, 95%
CI = 1.2-13.2), and Not washing hands after toilet (AOR = 0.114, 95% CI= 0.013-0.957) were
significantly associated with H. Pylori.
Conclusion: This study showed a statistically significant variation in some clinical chemistry
parameters of H. pylori patients compared to the control group. Therefore, routine screening of
clinical chemistry parameters should be considered for proper management of H. pylori-positive
patients
