Abstract:
The lack of a viable vaccine and the emergence of novel Mycobacterium tuberculosis (MTB)
strains that are particularly resistant to treatments, presage a complicated future situation.
Biosynthesized nanomaterials are currently proving to be a viable antibacterial therapeutic
option, including for MTB infection treatment. The goal of this work is to synthesize silver
nanoparticles (AgNPs) from Syzygium aromaticum seeds and investigate their antimicrobial,
anti-tubercular, and cytotoxic properties using zebrafish embryos and Artemia salina. The UV
spectrophotometer, SEM-EDAX, TEM and FTIR measurements were used to characterize the
AgNPs. Antibacterial activity was performed against S. aureus, P. aeruginosa, E. coli and K.
pneumoniae and exhibited potential inhibitory activity towards the bacterial cultures. The
MABA assay was used to investigate the anti-mycobacterial activity, and the AgNPs showed
the highest percentage of inhibition in both test concentrations (250 and 500 µg/ml).
